This 4GB RAM is 100% compatible with the Asus H81M-PLUS. For assistance in selecting the right RAM, we offer faster 1600MHz memory for your system. Thanks to the backward compatibility of our RAM to 1333MHz, you can also mix it with existing 1333MHz modules. RAM with ECC provides higher security through error detection and correction. The ECC function is supported if all existing memory is equipped with ECC. You should use UDIMM ECC RAM if existing modules already have ECC. It is possible to use different RAM sizes in the slots. The Dual Channel Mode is also supported by Intel's Flex Memory Technology. When using different RAM capacities, make sure that the memory in Memory Channel A is larger than the memory in Memory Channel B.