Yes, you can. On the Mac, the AOC is recognised correctly. However, the Mac Mini (in my case under macOS Mojave) cannot generate the maximum monitor resolution of 3840x2160. It stops at 2460x1440 - even with a special Mini Displayport to Displayport cable. With an HDMI cable, experience shows that the resolution should be even lower - but I haven't tried that. I therefore use the AOC on the PC, where it performs well. Since 2017, the Mac mini has been running the LG 34UB88-B (34", 3440 x 1440 pixels), with which I am very satisfied. Perhaps because LG produces screens for the iMacs, the Mac mini manages the full resolution of the LG 34UB88-B.