O'Keeffe's Working Hands Hand Cream - this concentrated hand cream provides relief, hydrates, and helps repair extremely dry, cracked hands. With daily use, it has been clinically proven that O’Keeffe’s Working Hands offers the following benefits: immediate moisture, creates a protective layer on the skin's surface, and helps prevent further moisture loss. For best results, apply the hand cream after washing your hands, bathing, and before going to bed, as these are the optimal times for moisturizing extremely dry skin.